FitBrains Blog


Archive for the ‘Neuroscience’ Category

Exercise Very Important For The Brain

Thursday, April 10th, 2008

We have no cure or perfect prevention against progressive dementia such as Alzheimer’s disease (AD). However, research over the past decade or more has established consistent links between lifestyle and the ability to delay the onset of such dementias. I have proposed a “Brain Health Lifestyle” to include five major factors: (1) physical activity, (2) mental stimulation, (3) socialization, (4) nutrition, (5) and spirituality.

 A recent interview on ABC News suggested that physical exercise may be the best means of preventing AD today, better than medications, intellectual activity, and supplements. Studies on mice bred to develop plaques in their brains consistent with AD were exposed to an exercise regimen or not. Those mice that exercised had 50 to 80 percent less plaque than the brains of mice that were passive. Other studies have demonstrated generation of new brain cells in animals that exercise and a relationship in humans between physical exercise and increased cognitive performance.

One important point is that our body does not operate in a fragmented manner. I describe the brain and body as a miraculous symphony. One system directly impacts another and both health and disease effects can be experienced as a result throughout the body. Exercise is one example of a behavior that has positive impact on multiple systems of the body including the brain. The same can be said for the other four brain health lifestyle behaviors noted above.

 While I am not yet sure that any one behavior such as exercise is better than another in promoting brain health, I do champion regular exercise as a very important behavior with positive brain health effects. My view is to approach brain health from an integrated manner using the five part brain health lifestyle. This approach fits with the complex integrated reality of our bodies and brains.

National Brain Health Policy

Friday, April 4th, 2008

 A recent report from the National Alzheimer’s Disease Association estimates nearly 10 million to 14 million of the baby boom generation (76 million strong) will be at risk for developing Alzheimer’s disease (AD). These numbers may actually underestimate the overall prevalence of boomers who will develop AD in their lifetime. This estimate places a heavy emotional, family and economic burden on the U.S. States given our current approach and over all understanding of the caregiver demands posed by AD. There is no reason to believe that similar nations across the world will be any different.

 One method to begin addressing the rising epidemic of dementia is to establish a national or world priority on the human brain and dementia. Citizens of the great planet Earth need to have a basic understanding of their brain, something that is completely missing even in 2008. We cannot expect citizens to care for their brain if they do not understand it or the importance of a proactive healthy lifestyle across their lifespan. One idea is to include basics of brain and brain health in every elementary curriculum in the world.
 National policy also has to prioritize research on treatment and prevention of dementia in ways we have not yet. Research is needed on how the brain functions, how diseases begin, new treatments for dementia, and innovation in the area of prevention. Health insurance companies should begin to incentivize lifestyles that promote brain health including lifelong learning, diets, meditation, and physical exercise. Those who continue to work or remain involved in society may be rewarded with some type of tax break. We need to think in terms of a Brain Enlightened Society.

Curiosity of Mental Energy

Friday, March 28th, 2008

Everyone experiences moments when we feel sluggish or perhaps hyperactive. Sometimes our brains feel like they are stuck in mud while other times we can solve almost any problem we confront. Interestingly, these cycles of mental energy or arousal may occur within a 24 hour time period, our circadian rhythm.

Some of us have our creative time or the time we perform best mentally in the morning hours. Others have their greatness expressed in the evening hours. There is no right versus wrong, simply different. Some people who work after midnight or in a mine shaft that has no natural light can experience a different circadian rhythm than those who work during the day and have exposure to natural sunlight. Sleep disorders, depression, and cognitive problems can result from altered sleep wake cycles.

There is no clear explanation for when arousal is highest in some and lowest for others. Some factors that can enhance or reduce mental energy or arousal include the following:

  •  Amount of daily exercise
  • Amount of sleep in 24 hours
  • Types of foods consumed
  • Water intake and hydration
  • Exposure to sunlight
  • Prescribed Medication and substance abuse
  • Mental challenge during the day

One of the best methods to increase mental energy is to increase blood flow to the brain through movement. This can include a brisk walk, aerobics, swimming, and even a dance. Fresh air can also rejuvenate a sluggish brain and increase water intake to remain hydrated during the day. Sugar can put the brain to sleep in some cases or make it feel like a good nap is needed. Caffeine can provide a quick boost, but may result in a type of mental crash later in the day.

 It is a good idea to first identify what periods of the day your brain is alert and productive and when it is sluggish. Try to identify what factors might be causing the onset of sluggishness and consider the tips suggested above.

A mentally alert brain is critical to health and to productivity.

What Exactly is a Stroke?

Monday, March 24th, 2008

Stroke is a clinical term that describes cell death in the brain. Stroke is a permanent and can result in significant functional impairment and even death. There are two types of strokes. The first is the most common and is referred to as ischemia. Nearly 80% of all strokes are ischemic and involves a blockage of blood flow that results in cell death. The other 20% of strokes are hemorrhagic that involves a bleeding outward from a weakened artery wall. As the blood gathers increased pressure can be placed on the surrounding brain tissue causing additional damage to the brain.

Both types of stroke are dangerous and can result in deficits of language, attention, information processing speed, and motor skills. Risk factors for stroke include advanced age, high blood pressure, diabetes, obesity, smoking, and poor diet. Typical preventative measures for stroke include the same protocol as used for the healthy heart. We have learned relatively recently how important blood flow to the brain is, particularly when we recognize that the brain commands 25% of the blood from every heart beat.

Creativity and the Brain

Sunday, March 16th, 2008

The human brain left to its own would likely create in unthinkable ways. Creativity most likely occurs when structure is limited and free flow of cognition can take place. It is suggested that Einstein’s most creative moments occurred when he took his morning walk or bike ride.

 Recent research suggests creativity relates to advanced age. It is important to note that older brains tend to lose a disproportionate number of brain cells in the frontal lobe, the area of the brain that helps to impose structure in our lives and perhaps on our thinking. With less capacity to impose structure, creativity may be unleashed.

 Given this, it is interesting to consider how much brain expression our world suppresses. Our classrooms impose enormous structure as do our jobs. We are highly routinized animals and probably rely as much on our subcortical brain regions as we do our cortex. We tend to refrain from new experiences or pathways to a similar endpoint. We also do not free our brains from structure long enough to express creativity.

 It is important to provide your brain with some time to simply think or exist without any task to be completed. Such time may help the brain express itself in ways it otherwise cannot. One prescription is to give your self 30 minutes a day of quiet or idle time. Einstein used such time to take a walk or ride a bike. By releasing structural restraints on your brain, you may create an entire new reality and future for your self and for others.

Chronic Stress and the Brain

Tuesday, March 4th, 2008

It seems everyone knows what “stress” is and what it feels like. Most of us agree that stress typically does not feel very good and places the mind and body in a precarious position. We know many things can cause stress and some of the reaction of being stressed is subjective, based on a personal perception. These examples might include being in traffic, waiting for an elevator, waiting for the doctor, or having to deal with perceived incompetence. However, more life threatening stressors such as near death from a motor vehicle accident, child abuse, sexual trauma, war, etc. can impose a more chronic form of stress.

 The brain reacts to stress by having a survival type instinct in which you will either run or fight the stressor. Some research indicates this is primarily a male response and that women may be better at actually working with the stressing agent to ameliorate the stress. Perhaps the latter is a more adaptive response to stress and might relate to the fact that women live longer than men.

 If the stressor does not go away the effects of the stress can become chronic and result in a clinical condition known as Post-Traumatic Stress disorder (PTSD) or chronic anxiety. Both of these conditions seem to have a hormonal component underlying them in which an explosion of hormones are released in the body—“stress response” and if not turned off can potentially do damage to the body and brain. Some of the hormones such as cortisol and glucocorticoids can actually cause potential damage to the brain.

 Animal and some human studies indicate that chronic stress with the persistent hormonal issue described above affects the hippocampus, structurally and functionally. The hippocampus is critical to memory and new learning and it is not coincidental that persons with chronic anxiety or PTSD have memory problems.

 Most people understand that it is important to first identify what causes their stress and then to try and develop more adaptive coping strategies to manage the stress in their lives. However, most people probably do not understand that such stress, if not managed can become chronic and may be a negative influence on brain function.

 It is a good idea to take some time and list two or three things that represent your chief stressors in life. Once you do this identify how you are presently coping or managing these stressors and try to determine how you might better reduce the negative effects of these stressors on your body and life.

Personalization with Mental Exercise

Thursday, February 28th, 2008

The market has witnessed a surge in the mental fitness software industry. More companies are purporting to be the best at training your brain and helping to sharpen cognitive or thinking skills.

One primary concern for this industry is to create software that is both fun and personally relevant. In fact, a primary focus of FitBrains is to be the leader of fun and personal relevance within the industry of mental exercise software. I believe that games can be both fun and have real life and personal value to a consumer.

We are all confronted with life’s daily challenges, each of which places demands on our brain for solutions or action. It is within this arena that FitBrains has captured the personal value: creating games that actually tap into real world challenges for the consumer. How many times have you lost a pair of socks in the laundry, forgotten the name of someone you met, misplaced your car keys or perhaps the car itself in the parking garage? Life provides us with real world games and the opportunity for real world mental exercise.

FitBrains takes this reality and champions mental exercise for the fun and personally relevant. We believe your arousal level will increase and you will be more deeply engaged in the mental exercise. Why? The task is more valuable or meaningful to you as a person. Companies that simply develop memory games or language games without the value of personal relevance are simply tasks to be completed. Personalization sparks long term commitment by the consumer for a healthy brain.

Mood and Cognitive Functions

Tuesday, February 19th, 2008

Your brain operates electrically and chemically. Neurochemicals form the dynamic foundation for our thoughts and emotions. Many neurochemicals have been identified while many more have not. Neurochemicals important to mood include Serotonin, Neuropinephrine, Neuroadrenaline, and Dopamine. These neurochemicals remain in healthy balance for most of us, but for some there is imbalance and a mood disorder can result.

 Effects of a mood disorder such as depression or mania include functional decline, interpersonal difficulty, and cognitive impairment. Depression is far more common than realized and represents a major chronic illness similar to high blood pressure. Depression not only affects the specific person, but it can also affect negatively those close to the patient and to potential colleagues. Depression and mania impairs thinking by reducing focus, attention, memory, and ability to execute plans. A depressed brain cannot process as deeply as necessary and this can result in rather significant cognitive impairment at times. Uncontrolled mania results in high distractibility, poor attention, and generally impaired cognitive functions across the board.

 Treatments for mood disorder are effective and include use of antidepressants, mood stabilizers for mania, psychotherapy, and following a brain health lifestyle as espoused by Dr. Nussbaum (www.paulnussbaum.com). Use of software similar to that of FitBrains that helps to stimulate mental activity can also be of some use for a brain that may be sluggish. The most important thing is to first identify depression when it arises, take it seriously, and get some help.

Alzheimer’s Disease in the United States

Wednesday, February 6th, 2008

A leading cause of brain disease in the United States is Alzheimer’s disease (AD). Named after Dr. Alzheimer who published a paper in 1907 describing the cognitive and functional decline of a female patient, this disease now affects nearly 5 million people. It is estimated that those affected by AD will triple by 2050.

 AD is the leading cause of progressive dementia. The disease typically erodes memory, spatial functions, language, personality and functional ability. The course of the disease approximates 10-12 years and those over the age of 85 are most at risk. Additional risk factors include female gender, family history of dementia, mood disorder, diabetes, and stroke. The cause is not known and there are no known cures or prevention.

 Treatments exist to help reduce the impact of particular symptoms and early detection has advanced significantly. New treatments are being researched and these should be to market in the near future. Lifestyle for brain health has also generated new attention and interest. One aspect of a brain health lifestyle is mental stimulation, a primary function of FitBrains. 

 If your loved one is experiencing memory loss and there is some concern about this change it is advised that he or she receive a comprehensive dementia examination. This will help to discern if the memory and other cognitive changes fall outside the range of normal and if dementia is present. Early detection is important because existing treatments can be started.
 

What is Dementia?

Wednesday, January 30th, 2008

Dementia is a clinical term used to describe loss of general intelligence, forgetfulness, language or other cognitive disturbance, personality change, and functional decline. There are nearly 70 or more causes of dementia, with the most common cause attributed to Alzheimer’s disease (AD). Other common causes of dementia include Vascular dementia (VaD), Lewy Body Dementia, Alcohol and substance based dementia, Huntington’s disease, Parkinson’s disease, depression, head injury, seizure disorder and many others.

Most causes of dementia are irreversible meaning the dementia will not be cured or get better. Only 3-5% of dementias are considered reversible. Examples of reversible dementia include B-12 deficiency, depression, and thyroid disorder. Alzheimer’s disease, the leading type of irreversible dementia affects those primarily over the age of 65. There is no know cause of AD nor is there any cure at this time.

Medications exist to treat the symptoms of dementia without actually stopping the underlying disease process. Often persons with dementia can become depressed, anxious, or even psychotic. These co-morbid conditions can be effectively treated with psychotropic medication, structure and a supervised environment.

Dementia extracts an enormous emotional toll and financial toll on families. Caregiving is fast becoming a major issue for baby boomers. Primary caregivers often suffer fatigue, depression, and physical illness as they wear down with the new role. Unfortunately dementia will become a bigger problem as the number of older persons on the planet increases.